Mesotherapy was started by a Frenchman, Michael Pistor, in 1948. It consists of injections of a mix of substances into the mesoderm, the layer of fat cells under the skin. This was believed to help in reduction of fat bulges and also of cellulite. The content mixture of the injection varies in accordance with each unique case and specific area to be treated. Mesotherapy can also assist in reducing pain, and in replenishing hair loss in both men and women.